Prototype 2 is an upcoming video game set for release on April 24, 2012 in North America and April 27, 2012 in Europe. It is currently under development by Canadian developer Radical Entertainment and is the sequel to 2009's Prototype. Like its original, the game is set to be published by Radical Entertainment's owner, Activision. The game is set to feature a new protagonist, Sergeant James Heller, as he goes on his quest to destroy the Blacklight Virus once and for all. The story is also one of revenge, as Heller wants to kill Mercer after his family was killed in the outbreak of the Blacklight Virus. Set in an open world shown in a third-person view perspective. The game was announced at the 2010 Spike VGA Awards with the tagline "Murder your Maker".

Gameplay

Like Alex Mercer, James Heller can shapeshift and assume other people’s identities and memories by consuming them. Taking peoples identities and shape-shifting into them has become more tactical. Due to Blackwatch's actions in the Yellow Zone, if the player assumes the role of a soldier, people will react back to him in a way that they show they want nothing to do with him. To make sure that enemies do not overwhelm the player, Radical has created a dodging system and new, more realistic AI. Heller will be able to use weapons in the game, such as ripping the cannon off of a tank and using it against enemies. Heller can also sneak up on unsuspecting human enemies, inject the Blacklight virus in them and create a "BioBomb" out of them to blow up objects, enemies and such. James Heller also has improved strength, movement, invulnerability (self-healing and endurance), and has a sonar sense. The sonar includes a new pulse ability that highlights the key features of an environment to make it easier for the player to find something or someone, instead of looking in a large crowd for a person with an icon above their head. Radical has stated that the powers will be more meaningful, they will come in mutations and upgrades that let players decide how they want to play as Heller.

To give gamers more power in the game, the developers have added tendrils. Tendrils sprout from Heller's arm and can be used for a variety of purposes, such as reaching out into the game environment. Players can use tendrils to smash objects into other objects, such as a car into a tank or vice-versa. Also, players can string up enemies into "webs", much like the abilities of Spider-Man, to make them vulnerable for further attacks. Players are able to rip enemies in half. Players will be able to dismember all enemies, a force that will become more useful as the game progresses. There are many more ways to kill enemies, ranging from throwing a tank at group of Blackwatch soldiers, hacking off a mutants head or using the tendrils. In the original game, there were limited options that allowed you to destroy airborne enemies. in Prototype 2 ,however, they have many more options available such as an uppercut, or the use of tendrils. When the player picks up a person, the game will no longer automatically kill them, starting a combat sequence, Radical has tweaked this to become a useful tool, an intimidation factor. 

Unlike the original, Heller will not be given his missions by a person, but rather choose them himself. Hacking onto Blacknet, a system of Blackwatch that details military operations and the three areas of NYZ, Heller chooses his own missions. Blacknet will allow Heller to find operations that he can disrupt or take control of for his own purposes, or find important people that will allow him to learn more about what he has become because of the Blacklight virus. It will also help him find out more about Alex Mercer and what his connections are to his family's deaths. The missions that are selectable can be sidequests (sub-missions) or extensions to the main quest that tell Heller more about the Blacklight Virus.